Like all medications, Spravato (esketamine) can cause side effects. The good news is that these effects are usually short-lived, closely monitored, and managed in a safe clinical environment. For most patients, the benefits of Spravato in reducing depression symptoms far outweigh the temporary discomforts that may occur during or after treatment.
At Being Health in New York City, we prioritize safety and patient comfort throughout the entire treatment process.
Common Side Effects of Spravato
Most side effects occur during or shortly after a treatment session and fade within a few hours. Patients are always monitored for a minimum of 2 hours, until it is safe to leave.
Temporary Effects May Include:
- Dizziness or lightheadedness
- Dissociation (feeling “floaty,” dreamlike, or detached)
- Nausea or mild stomach upset
- Sleepiness or fatigue
While these experiences can feel unusual, they are expected and generally not harmful when treatment is delivered under proper medical supervision.
Less Common Side Effects
Some patients may also experience:
- Temporary increase in blood pressure
- Headache
- Mild anxiety or restlessness
These are typically mild, resolve the same day, and are carefully managed by your care team.
Safety First at Being Health
Spravato can only be administered in certified treatment centers because of its potential side effects. At Being Health, we follow gold-standard safety protocols to protect every patient:
- Continuous monitoring: Blood pressure, heart rate, and overall wellbeing are tracked throughout the session.
- Immediate support: Clinicians remain present to respond quickly to any discomfort.
- Safe environment: Treatment rooms are designed to be calm and private, helping patients feel at ease.
- Post-treatment care: Patients rest and recover until stable, and then are discharged.
How Long Do Spravato Side Effects Last?
- Most side effects resolve within a few hours after treatment.
- Patients generally return to normal activities the next day.
- Side effects tend to lessen over time as patients continue treatment.
Importantly, patients often report that the relief from depression symptoms outweighs the temporary side effects of treatment.
Frequently Asked Questions About Spravato Side Effects
Will Spravato make me feel "high"?
Spravato can cause dissociation or dreamlike sensations, but this is temporary and closely monitored.
Can I drive after treatment?
No. Patients must arrange for transportation home and should not drive until the next day.
Are side effects dangerous?
Serious risks are rare. With proper monitoring in a certified clinic, Spravato is considered safe and well-tolerated.
Next Steps
If you’re considering Spravato, knowing what to expect can help you feel prepared and confident.
For more personalized answers and to learn if Spravato is right for you, schedule a consultation with Being Health today or give us a call at 888-668-7600.
