Spravato (esketamine) is an FDA-approved treatment for adults with treatment-resistant depression. Since its approval in 2019, Since its approval in 2019, Spravato has been carefully studied in clinical trials and continues to be used in real-world care. Many people find it can provide meaningful improvement when other treatments haven’t worked.
At Being Health in New York City, we provide this evidence-based treatment to patients in a safe supported, and clinically supervised environment.
Clinical Trial Results: Up to 70% Response Rates
Large-scale clinical trials found that Spravato, combined with an oral antidepressant, helped many adults with treatment resistant depression who had not responded to prior medications.
- Response Rate: Up to 70% of patients experienced a significant reduction in depressive symptoms.
- Rapid Improvement: Many patients reported improvements in mood within the first 2–4 weeks of treatment.
- Remission Rates: Some patients achieved full remission, meaning their depressive symptoms became minimal or absent.
These results supported the FDA’s approval of Spravato for treatment-resistant depression in 2019. While individual results vary, clinical evidence shows that Spravato can be a valuable option for people who haven’t found relief with standard antidepressants.
Real-World Outcomes: Improvements Within Weeks
Beyond clinical trials, real-world results continue to reinforce Spravato’s potential benefits. At clinics across the country, including Being Health, patients may experience:
- Symptom relief within the first 2 weeks of treatment
- Improved daily functioning, including improvements in energy, motivation, concentration
- Enhanced quality of life and renewed sense of hope
While every patient’s experience is unique, the outcomes we see in practice align closely with what was demonstrated in clinical trials. At Being Health, treatment is always tailored to the individual, with close monitoring and support throughout the process.
FDA Approval for Suicidality
Spravato is not only approved for treatment-resistant depression but also for Major depressive disorder (MDD) with suicidal thoughts or behaviors.
This makes it one of the few FDA-approved treatments available for patients in acute crisis, offering a fast-acting option when timely intervention matters most.
Factors That Influence Success
Like all treatments, results vary. Success rates depend on:
- Treatment adherence: Following the recommended protocol (twice weekly in the first month, then tapering)
- Supportive care: Combining Spravato with psychotherapy and lifestyle support often enhances results
- Individual biology: Some patients may respond more strongly than others
At Being Health, we tailor care plans to each patient’s needs, maximizing the likelihood of success.
Why Spravato Can Be Life-Changing
For patients who have cycled through multiple antidepressants without relief, Spravato offers:
- Rapid improvement compared to traditional medications
- FDA-approved safety and oversight
- Insurance coverage with many major providers in NYC
- A new path forward when options feel limited
While results vary, the evidence is clear: Spravato can be life-changing for many patients who haven’t found relief elsewhere.
Frequently Asked Questions About Spravato Success Rates
How quickly will I know if Spravato is working?
Some patients notice changes within the first few sessions. For others, improvement builds gradually over 2–4 weeks.
Does Spravato work for everyone?
No treatment works for every patient. However, clinical data shows high response rates compared to other options for treatment-resistant depression.
Can Spravato put depression into remission?
Yes. Some patients achieve remission, meaning little to no depressive symptoms, though ongoing maintenance may be needed.
Next Steps
If you’ve tried multiple antidepressants without success, Spravato could be the next step in your treatment journey.
For more personalized answers and to learn if Spravato is right for you, schedule a consultation with Being Health today or give us a call at 888-668-7600.
